Lincolnshire fell just six points shy of promotion last year, finishing fifth on 439 points.
They will be desperate to go at least one better this year, having not competed in Division One since 2006.
The county picked up two race wins last year with Alex Wray touching first in the 16/17 Yrs 100m Freestyle and Tara Haworth claiming maximum points in the 16/17 Yrs 100m Butterfly.
Lincoln Vulcans swimmer Haworth returns for her final year in the Championships, having made four finals at the British Summer Championships earlier in the season.
The county looks to have a strong hand in the oldest age group. City of Lincoln Pentaqua swimmer Bethany Walker won 50m Breast bronze at the British Summer Champs then landed 100m Free gold at the ASA Summer Nationals the following week.
Deepings’ Isabel Spinley is also well ranked, having finished fourth over both 100m and 200m Fly at the British Summer Champs.
Meanwhile, Matthew Broughton’s PB 1:12.30 puts him amongst the favourites in the 12/13 Yrs 100m Breaststroke while Lincoln Vulcans’ Sophie Hart won bronzes over 50m and 200m Backstroke at this year’s ASA Summer Nationals